Associate Director, Quantitative Pharmacology & Pharmacometrics - Mechanistic Modeling, Immunology Job at Merck, West Point, PA

  • Merck
  • West Point, PA

Job Description

Merck seeks an Associate Director in Quantitative Pharmacology and Pharmacometrics with expertise in mechanistic modeling for immunology drug development. The role involves independently designing and executing model-based analyses to inform translational research and clinical development decisions across cross-functional teams.

Responsibilities

  • Design and execute mechanistic modeling analyses to address translational and drug development questions in immunology
  • Develop and apply PK/PD, PBPK, QSP, and other mechanistic models integrating preclinical and clinical data to inform dose selection and trial design
  • Conduct clinical trial simulations, comparator modeling, and model-based analyses supporting go/no-go decisions
  • Partner with cross-functional teams and external vendors to develop aligned drug development strategies
  • Present scientific findings and communicate quantitative results to diverse scientific audiences

Requirements

  • Ph.D. with 4+ years or PharmD with 6+ years or MS with 8+ years in pharmaceutical drug development, regulatory agencies, or academia
  • Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics, biostatistics, computational biology, or biomedical engineering
  • Hands-on experience performing population PK/PKPD/QSP modeling using Phoenix, R, Matlab, NONMEM, or Monolix
  • Advanced skills in experimental design, mathematical problem-solving, and data analysis interpretation
  • Proficiency in written and verbal communication and interdisciplinary collaboration

Compensation: $156,900-$247,000 base

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